Fri Mar 07 2025

30 articles - From Friday Feb 28 2025 to Friday Mar 07 2025

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Guidelines

Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…

Liver Transpl

The 2024 ILTS-ILCA consensus recommendations for liver transplantation for hepatocellular carcinoma and intrahepatic cholangiocarcinoma.

The multidisciplinary participants in the consensus conference provided up-to-date recommendations regarding the selection and management of patients with liver cancer being considered for LT. Although participants deferred to center protocols in many cases, there was great interest in safely expanding access to LT for patients with larger tumor burden and biologically amenable lesions.

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Meta-analysis

meta-analyses and systematic reviews

Pancreatology

Inflammatory markers in predicting survival in pancreatic cancer: A Systematic review and Meta-Analysis.

Furthermore, NLR and PLR show significant association with malignancy in PCN (OR 3.07 and HR 2.42, respectively). NLR and PLR effectively predicted PC outcomes and hold potential for evaluating therapeutic responses and identifying candidates for additional treatment strategies in advanced disease.

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Original articles

RCT, clinical trials, retrospective studies, etc…

Am J Clin Nutr

A Bayesian Analysis of the VITAL Trial: Effects of Omega-3 Fatty Acid Supplementation on Cardiovascular Events.

Bayesian analyses of VITAL incorporating previous RCT evidence suggest that daily omega-3 FA supplementation robustly lowers risk of coronary events but not stroke, providing enhanced support for the primary prevention use of omega-3 FA supplementation for coronary events. (VITAL clinicaltrials.gov identifier NCT01169259).

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Biomarkers of dietary PUFA intake in childhood and adolescence in relation to cardiometabolic risk factors in young adulthood: a prospective cohort study in Sweden.

Plasma phospholipid proportions of LA and ALA, biomarkers of vegetable oil intake, during childhood and adolescence were inversely associated with measures of obesity and cardiometabolic health in young adulthood, with a potential sex difference. These findings accord with short-term feeding trials suggesting a possible preventive role of LA on body fat accumulation.

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Continuous glucose monitor overestimates glycemia, with the magnitude of bias varying by postprandial test and individual - A randomized crossover trial.

CGM overestimated glycemic responses in numerous contexts. At times this can mischaracterize the GI. In addition, there is inter-individual heterogeneity of the accuracy of CGM to estimate fasting glucose concentrations. Correction for this difference reduces, but does not eliminate, postprandial overestimate of glycemia by CGM. Caution should be applied when inferring absolute or relative glycemic responses to foods using CGM, and capillary sampling should be prioritised for accurate quantification of glycemic response. Clinical trial registry

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Post-cardiovascular disease healthy lifestyle, inflammation and metabolic biomarkers, and risk of dementia: a population-based longitudinal study.

Adherence to healthy lifestyle behaviors is significantly associated with a lower risk of dementia in individuals with CVD. The observed associations may be partly explained by a reduction in systemic inflammation and the promotion of metabolic balance.

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Reducing Cardiometabolic Diseases Risk dietary pattern in the Chinese population with dyslipidemia: a single-center, open-label, randomized, dietary intervention study.

Compared to the control group, the RCMDR dietary pattern intervention lowered cardiometabolic risk, blood lipids, blood pressure, abdominal obesity and circulating Hcy level among Chinese population with dyslipidemia. Chinese Clinical Trial Registry (ChiCTR2300072472),

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Validation of a food frequency questionnaire for measuring dietary intake of isoflavones and lignans using the method of triads.

FFQ shows reasonable performance in measuring habitual intake of isoflavones and lignans, while urinary isoflavones are unlikely to perform as well as FFQ-based assessment of dietary isoflavones.

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Inflamm Bowel Dis

Dietary Nut and Legume Intake and Risk of Crohn's Disease and Ulcerative Colitis.

Nut and legume intake were not associated with CD or UC risk. However, higher nut intake decreased CD risk in overweight or obese individuals. Thus, personalized-risk stratification, rather than generalized dietary recommendations, may be important for IBD prevention strategies.

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Efficacy and Safety of Etrasimod in Patients With Moderately to Severely Active Ulcerative Colitis Stratified by Baseline Modified Mayo Score: A Post Hoc Analysis From the Phase 3 ELEVATE UC Clinical Program.

At week 12, etrasimod showed greater reductions in disease activity and higher rates of clinical response vs placebo in patients with either moderately or severely active disease at baseline. The safety profile of etrasimod was consistent with the overall trial population and was unimpacted by baseline disease activity. NCT03945188; NCT03996369.

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Higher-Dose Infliximab Induction Achieves Better Maintenance Trough Levels in a National Pediatric IBD Cohort-A Retrospective Study.

Our real-world data show that 5 mg/kg infliximab induction does not achieve target TLs in most children with CD. Higher-dose regimens should be considered, especially if proactive therapeutic drug monitoring is not available.

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J Crohns Colitis

Higher Dietary Glycemic Index, but not Glycemic Load, is Associated with Increased Risk of Ulcerative Colitis: A Prospective Cohort Study.

No significant associations were found between dietary glycemic load with risk of CD and UC. A higher dietary glycemic index, but not glycemic load, is associated with an increased risk of UC, underscoring the importance of considering glycemic index in dietary recommendations for UC prevention.

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Independent Predictors of 90-Day Readmission in Patients with Inflammatory Bowel Disease: A Nationwide Retrospective Study.

This study identifies several risk factors for readmission in patients with IBD, many of which are potentially modifiable psychosocial factors. Closer follow-up, possibly via virtual modalities, as well as alternative treatment strategies, should be considered in patients with IBD at higher risk of readmission.

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Intestinal Ultrasound as a Prognostic Tool in New-Onset Ulcerative Colitis - A Copenhagen IBD Cohort Study.

Findings by intestinal ultrasound at the time of diagnosis predict early colectomy risk in UC. Our results underscore that transmural remission is a feasible treatment target in early UC, and significantly impacts the disease course.

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Liver Transpl

To Err Is Robot - an analysis of complications following robotic donor hepatectomy.

Although RDH appears to be safe, critical complications can occur in a minority of cases. Safety lies in flattening the learning curve.

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Pancreas

Coupled Plasma Filtration and Adsorption in Eliminating Inflammatory Mediators and Enhancing Sublingual Microcirculation in Severe Acute Pancreatitis.

The application of CPFA in SAP patients effectively eliminates inflammatory mediators and enhances microcirculation, leading to improved clinical outcomes and reduced mortality rates.

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Efficacy of Neoadjuvant Therapy for Resectable Pancreatic Cancer Might be Limited to Biologically Borderline Resectable Cases.

The efficacy of NAT for RPC might be limited to the subset of patients with high TM.

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Usefulness and Safety of Endoscopic Nasobiliary Drainage for Type 1 Autoimmune Pancreatitis.

Although ENBD causes discomfort and the risk of self-removal, it differentiates AIP from malignant tumors, evaluates steroid effects using real-time cholangiography, and reduces the number of required ERCP procedures. ENBD could be one of the drainage options for type 1 AIP, depending on patients' background.

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Pancreatology

Circulating cyclophilin A levels elevate in animal models and can predict mortality in patients with acute pancreatitis.

Circulating CypA levels are significantly increased in mouse CER-AP and hamster HTG-AP models. We have identified a novel association of raised plasma CypA levels with severity of HTG-AP and confirmed its significant prognostic ability to predict mortality in AP patients.

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Early response evaluation using CT and CA 19-9 in patients with pancreatic cancer of all stages undergoing first-line FOLFIRINOX treatment.

In the CT/CA 19-9 response dataset (n = 242), integrated CT and CA 19-9 responses revealed the shortest OS in patients with either PD or increased CA 19-9 (n = 74; median OS, 14.3 months), followed by PR/SD with decreased CA 19-9 (n = 113; median OS, 19.8 months; P = .003), and PR/SD with normalized CA 19-9 (n = 55; median OS, 23.6 months; P = .04). Our combined evaluation of CT and CA 19-9 responses successfully stratified the survival of patients with PDAC treated with FOLFIRINOX, irrespective of disease stage.

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Evolving trends in interventions and outcomes for acute biliary pancreatitis during pregnancy: A two-decade analysis.

Pregnant women represent a significant portion of hospitalized ABP cases, paralleling increases in age, comorbidities, and obesity rates. Racial disparities are linked to higher odds of SAP, though comorbidities have a dominant effect. There has been an increase in guideline-recommended procedures (ERCP and cholecystectomy); however, further research is needed to address the implementation gap, considering the increased complexity of pregnant women with ABP.

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Laparoscopic versus open Frey procedure: Comparative analysis of short and long-term outcomes.

Laparoscopic Frey procedure is an efficient and safe intervention, which provides al the advantages of the minimally invasive approach.

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Vascular stent graft for the treatment of post-pancreaticoduodenectomy hemorrhage and risk factors for rebleeding.

Vascular stent graft is effective and safe for PPH, especially at the site of the GDA stump and the CHA-PHA. Recurrent bleeding is not rare with such treatment, and BMI and pancreatic fistula are independent risk factors for rebleeding.

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Reviews&Editorials

Plenty of the editorials are available as full text through the publisher website using the provided link

Am J Clin Nutr

Extending the prevention paradigm for cardiometabolic diseases to target dementia through multiple low-risk lifestyle behaviors: a story of adherence.

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Urinary creatinine excretion-a standard that requires further calibration.

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Pancreatology

"Harnessing the power of organoids for improved outcomes in pancreatic cancer".

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The evolving landscape of EUS utilization in the management of pancreatic cystic neoplasms.

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Miscellaneous

misc publications eg case reports, tools of the trade, images of the month, etc…

Liver Transpl

No RETREAT: Moving forward in post-transplant HCC recurrence prediction.

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The long and winding road to maximize the benefit of Liver Transplantation.

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Letters&Replies

Letters to the editors and authors’ replies

Am J Clin Nutr

Phenylketonuria in adults: we know plenty, but there is much more to learn.

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